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KMID : 0861020020170020111
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Korea Journal of Herbology
2002 Volume.17 No. 2 p.111 ~ p.117
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Vasodilation Effect of the Water Extract of Rheum palmatum L. in Rat Thoracic Aorta
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Abstract
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Objectives : We have examined the relaxational response to the water extract of Rheum palmatum L. in isolated thoracic aorta from sprague dawley (SD) rat in the presence and absence of endothelium.
Methods : Rat thoracic aorta was investigated in vessel segments suspended for isometric tension recording by polygraph. Responses to Rhizoma Rhei were investigated in vessels precontracted with 5-hydroxytryptamine. We found that the thoracic aorta segments responded to the water extract of Rheum palmatum L. (ERP) with a dose-dependent vasorelaxation.
Results : We found that
1. The thoracic aorta segments responded to ERP with a dose-dependent vasodilation.
2. The 5-HT induced contraction at 10^-4M were inhibited by 85.8% after addition of the 0.1 g/mL water extract of ERP.
3. The 5-HT induced contraction at 10^-4M with and without endothelium were inhibited by 86.4% and 85.8% after addition of the 0.1g/mL ERP.
4. After pre-treatment of the thoracic aorta with 10^-4M N^G-monomethyl-L-arginine (L-NMMA), inducible nitric oxide synthase inhibitor, the vessels has not response to the contraction.
Conclusion : In conclusion, ERP induced relaxation in the isolated rat thoracic aorta were composed of dose-dependent relaxation and it has potent vasodilation.
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